Symbol: Name: ID: |
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) GFS:1562 |
Gene name: | TFAP2B |
Chromosome: | 6p12 |
Previous Symbols: | |
Previous Names: | transcription factor AP-2 beta (activating enhancer-binding protein 2 beta) |
Aliases: | AP2-B |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:104672 | Rat Genome Database ID: | RGD:1306321 |
HGNC ID: | HGNC:11743 | RefSeq IDs: | NM_003221 |
Entrez Gene ID: | 7021 | Ensembl Gene ID: | ENSG00000008196 |
VEGA IDs: | OTTHUMG00000014836 | UniProt ID: | Q92481 |
UCSC ID: | uc003pag.2 | OMIM ID: | 601601 |
Pubmed: | PMID7555706 PMID 8661133 | ||
CCDS IDs: | CCDSCCDS4934.2 |
The TFAP2B gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
Products for TFAP2B gene
Catalog | Product Name | Application | Company |
GFS:E01562 | transcription factor AP-2 beta (activating enhancer binding protein 2 beta); ELISA kit | ELISA | n/a |
GFS:A01562 | transcription factor AP-2 beta (activating enhancer binding protein 2 beta); Anti | ANTIBODIES | n/a |
GFS:P01562 | transcription factor AP-2 beta (activating enhancer binding protein 2 beta); Protien | Protien | n/a |