Symbol: Name: ID: |
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) GFS:1561 |
Gene name: | TFAP2A |
Chromosome: | 6pter-p22.3 |
Previous Symbols: | TFAP2, AP2TF |
Previous Names: | transcription factor AP-2 alpha (activating enhancer-binding protein 2 alpha) |
Aliases: | AP-2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:104671 | Rat Genome Database ID: | RGD:1310267 |
HGNC ID: | HGNC:11742 | RefSeq IDs: | NM_001032280 |
Entrez Gene ID: | 7020 | Ensembl Gene ID: | ENSG00000137203 |
VEGA IDs: | OTTHUMG00000014235 | UniProt ID: | P05549 |
UCSC ID: | uc003myr.2 | OMIM ID: | 107580 |
Pubmed: | PMID1916817 PMID 3063603 | ||
CCDS IDs: | CCDSCCDS4510.1 CCDS CCDS34337.1 CCDS CCDS43422.1 |
Transcription factor AP-2 alpha (Activating enhancer binding Protein 2 alpha), also known as TFAP2A, is a protein that in humans is encoded by the TFAP2A gene. The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle (By similarity).
Products for TFAP2A gene
Catalog | Product Name | Application | Company |
GFS:E01561 | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); ELISA kit | ELISA | n/a |
GFS:A01561 | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); Anti | ANTIBODIES | n/a |
GFS:P01561 | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); Protien | Protien | n/a |