Symbol: Name: ID: |
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) GFS:1470 |
Gene name: | TCEB3 |
Chromosome: | 1p36.1 |
Previous Symbols: | |
Previous Names: | transcription elongation factor B (SIII), polypeptide 3 (110kD, elongin A) |
Aliases: | SIII, TCEB3A |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1351315 | Rat Genome Database ID: | RGD:3827 |
HGNC ID: | HGNC:11620 | RefSeq IDs: | NM_003198 |
Entrez Gene ID: | 6924 | Ensembl Gene ID: | ENSG00000011007 |
VEGA IDs: | OTTHUMG00000002957 | UniProt ID: | Q14241 |
UCSC ID: | uc001bho.2 | OMIM ID: | 600786 |
Pubmed: | PMID8586449 PMID 7660129 | ||
CCDS IDs: | CCDSCCDS239.2 |
Transcription elongation factor B polypeptide 3 is a protein that in humans is encoded by the TCEB3 gene. This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
Products for TCEB3 gene
Catalog | Product Name | Application | Company |
GFS:E01470 | transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A); ELISA kit | ELISA | n/a |
GFS:A01470 | transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A); Anti | ANTIBODIES | n/a |
GFS:P01470 | transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A); Protien | Protien | n/a |