Symbol: Name: ID: |
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) GFS:1468 |
Gene name: | TCEB2 |
Chromosome: | 16p12.3 |
Previous Symbols: | |
Previous Names: | transcription elongation factor B (SIII), polypeptide 2 (18kD, elongin B) |
Aliases: | SIII |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914923 | Rat Genome Database ID: | RGD:621200 |
HGNC ID: | HGNC:11619 | RefSeq IDs: | NM_007108 |
Entrez Gene ID: | 6923 | Ensembl Gene ID: | ENSG00000103363 |
VEGA IDs: | OTTHUMG00000154125 | UniProt ID: | Q15370 |
UCSC ID: | uc002crm.2 | OMIM ID: | 600787 |
Pubmed: | PMID7638163 | ||
CCDS IDs: | CCDSCCDS32374.1 CCDS CCDS45387.1 |
Transcription elongation factor B polypeptide 2 is a protein that in humans is encoded by the TCEB2 gene. This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq].
Products for TCEB2 gene
Catalog | Product Name | Application | Company |
GFS:E01468 | transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B); ELISA kit | ELISA | n/a |
GFS:A01468 | transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B); Anti | ANTIBODIES | n/a |
GFS:P01468 | transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B); Protien | Protien | n/a |