Symbol: Name: ID: |
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) GFS:1467 |
Gene name: | TCEB1 |
Chromosome: | 8q13.3 |
Previous Symbols: | |
Previous Names: | transcription elongation factor B (SIII), polypeptide 1 (15kD, elongin C) |
Aliases: | SIII |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1915173 | Rat Genome Database ID: | RGD:620658 |
HGNC ID: | HGNC:11617 | RefSeq IDs: | NM_005648 |
Entrez Gene ID: | 6921 | Ensembl Gene ID: | ENSG00000154582 |
VEGA IDs: | OTTHUMG00000164501 | UniProt ID: | Q15369 |
UCSC ID: | uc003xzx.1 | OMIM ID: | 600788 |
Pubmed: | PMID7821821 PMID 7660122 | ||
CCDS IDs: | CCDSCCDS34910.1 |
Transcription elongation factor B polypeptide 1 is a protein that in humans is encoded by the TCEB1 gene. This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq].
Products for TCEB1 gene
Catalog | Product Name | Application | Company |
GFS:E01467 | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); ELISA kit | ELISA | n/a |
GFS:A01467 | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); Anti | ANTIBODIES | n/a |
GFS:P01467 | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); Protien | Protien | n/a |