Symbol: Name: ID: |
TRIP10 thyroid hormone receptor interactor 10 GFS:2121 |
Gene name: | TRIP10 |
Chromosome: | 19p13.3 |
Previous Symbols: | STOT |
Previous Names: | salt tolerator |
Aliases: | STP, HSTP, CIP4 |
Name Aliases: | Cdc42-interacting protein |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2146901 | Rat Genome Database ID: | RGD:621145 |
HGNC ID: | HGNC:12304 | RefSeq IDs: | NM_004240 |
Entrez Gene ID: | 9322 | Ensembl Gene ID: | ENSG00000125733 |
VEGA IDs: | OTTHUMG00000150255 | UniProt ID: | Q15642 |
UCSC ID: | uc002mfr.2 | OMIM ID: | 604504 |
Pubmed: | PMID7776974 PMID 9210375 PMID 11294612 | ||
CCDS IDs: | CCDSCCDS12172.1 |
Cdc42-interacting protein 4 is a protein that in humans is encoded by the TRIP10 gene. Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
Products for TRIP10 gene
Catalog | Product Name | Application | Company |
GFS:E02121 | thyroid hormone receptor interactor 10; ELISA kit | ELISA | n/a |
GFS:A02121 | thyroid hormone receptor interactor 10; Anti | ANTIBODIES | n/a |
GFS:P02121 | thyroid hormone receptor interactor 10; Protien | Protien | n/a |