Symbol: Name: ID: |
SYT1 synaptotagmin I GFS:1368 |
Gene name: | SYT1 |
Chromosome: | 12cen-q21 |
Previous Symbols: | SYT, SVP65 |
Previous Names: | |
Aliases: | P65 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:99667 | Rat Genome Database ID: | RGD:3803 |
HGNC ID: | HGNC:11509 | RefSeq IDs: | NM_001135805 |
Entrez Gene ID: | 6857 | Ensembl Gene ID: | ENSG00000067715 |
VEGA IDs: | OTTHUMG00000134326 | UniProt ID: | P21579 |
UCSC ID: | uc001syv.2 | OMIM ID: | 185605 |
Pubmed: | PMID1840599 | ||
CCDS IDs: | CCDSCCDS9017.1 |
Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene. The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM].
May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
Products for SYT1 gene
Catalog | Product Name | Application | Company |
GFS:E01368 | synaptotagmin I; ELISA kit | ELISA | n/a |
GFS:A01368 | synaptotagmin I; Anti | ANTIBODIES | n/a |
GFS:P01368 | synaptotagmin I; Protien | Protien | n/a |