Symbol: Name: ID: |
SPINK5 serine peptidase inhibitor, Kazal type 5 GFS:4673 |
Gene name: | SPINK5 |
Chromosome: | 5q31-q32 |
Previous Symbols: | |
Previous Names: | serine protease inhibitor, Kazal type 5 |
Aliases: | VAKTI, LEKTI, LETKI, NETS, NS, FLJ21544, FLJ97536, FLJ97596, FLJ99794, DKFZp686K19184 |
Name Aliases: | lymphoepithelial Kazal-type-related inhibitor |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1919682 | Rat Genome Database ID: | RGD:1306540 |
HGNC ID: | HGNC:15464 | RefSeq IDs: | NM_001127698 |
Entrez Gene ID: | 11005 | Ensembl Gene ID: | |
VEGA IDs: | OTTHUMG00000134305 | UniProt ID: | Q9NQ38 |
UCSC ID: | uc003loy.2 | OMIM ID: | 605010 |
Pubmed: | PMID10419450 | ||
CCDS IDs: | CCDSCCDS43382.1 CCDS CCDS47300.1 CCDS CCDS47301.1 |
Lympho-epithelial Kazal-type-related inhibitor (LEKTI) also known as serine protease inhibitor Kazal-type 5 (SPINK5) is a protein that in humans is encoded by the SPINK5 gene.
This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The inhibitor may play a role in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucous epithelia. Mutations may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin.
Products for SPINK5 gene
Catalog | Product Name | Application | Company |
GFS:E04673 | serine peptidase inhibitor, Kazal type 5; ELISA kit | ELISA | n/a |
GFS:A04673 | serine peptidase inhibitor, Kazal type 5; Anti | ANTIBODIES | n/a |
GFS:P04673 | serine peptidase inhibitor, Kazal type 5; Protien | Protien | n/a |