Symbol: Name: ID: |
SPAG8 sperm associated antigen 8 GFS:3522 |
Gene name: | SPAG8 |
Chromosome: | 9p13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | hSMP-1, HSD-1, BS-84, SPAG3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:3056295 | Rat Genome Database ID: | RGD:1307079 |
HGNC ID: | HGNC:14105 | RefSeq IDs: | NM_001039592 |
Entrez Gene ID: | 26206 | Ensembl Gene ID: | ENSG00000137098 |
VEGA IDs: | OTTHUMG00000019875 | UniProt ID: | Q99932 |
UCSC ID: | uc003zyg.2 | OMIM ID: | 605731 |
Pubmed: | PMID10500252 PMID 8788182 | ||
CCDS IDs: | CCDSCCDS6592.1 CCDS CCDS43798.1 |
Sperm-associated antigen 8 is a protein that in humans is encoded by the SPAG8 gene.
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. [provided by RefSeq, Jul 2008].
Function: May play a role in fertility and microtubule formation through interaction with RANBP9.
Products for SPAG8 gene
Catalog | Product Name | Application | Company |
GFS:E03522 | sperm associated antigen 8; ELISA kit | ELISA | n/a |
GFS:A03522 | sperm associated antigen 8; Anti | ANTIBODIES | n/a |
GFS:P03522 | sperm associated antigen 8; Protien | Protien | n/a |