Symbol: Name: ID: |
SNX15 sorting nexin 15 GFS:4259 |
Gene name: | SNX15 |
Chromosome: | 11q12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1916274 | Rat Genome Database ID: | RGD:1305803 |
HGNC ID: | HGNC:14978 | RefSeq IDs: | NM_013306 |
Entrez Gene ID: | 29907 | Ensembl Gene ID: | ENSG00000110025 |
VEGA IDs: | OTTHUMG00000037387 | UniProt ID: | Q9NRS6 |
UCSC ID: | uc001ocj.2 | OMIM ID: | 605964 |
Pubmed: | PMID11208079 | ||
CCDS IDs: | CCDSCCDS8089.1 CCDS CCDS8090.1 |
Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010].
Function: May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.
Products for SNX15 gene
Catalog | Product Name | Application | Company |
GFS:E04259 | sorting nexin 15; ELISA kit | ELISA | n/a |
GFS:A04259 | sorting nexin 15; Anti | ANTIBODIES | n/a |
GFS:P04259 | sorting nexin 15; Protien | Protien | n/a |