Symbol: Name: ID: |
SNX1 sorting nexin 1 GFS:1071 |
Gene name: | SNX1 |
Chromosome: | 15q22.31 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SNX1A, MGC8664, HsT17379, Vps5 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1928395 | Rat Genome Database ID: | RGD:68935 |
HGNC ID: | HGNC:11172 | RefSeq IDs: | NM_003099 |
Entrez Gene ID: | 6642 | Ensembl Gene ID: | ENSG00000028528 |
VEGA IDs: | UniProt ID: | Q13596 | |
UCSC ID: | uc002amv.2 | OMIM ID: | 601272 |
Pubmed: | PMID8638121 | ||
CCDS IDs: | CCDSCCDS32266.1 CCDS CCDS32267.1 CCDS CCDS32268.1 |
SNX1 encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq].
May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
Products for SNX1 gene
Catalog | Product Name | Application | Company |
GFS:E01071 | sorting nexin 1; ELISA kit | ELISA | n/a |
GFS:A01071 | sorting nexin 1; Anti | ANTIBODIES | n/a |
GFS:P01071 | sorting nexin 1; Protien | Protien | n/a |