Symbol: Name: ID: |
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 GFS:1248 |
Gene name: | STAM2 |
Chromosome: | 2q23.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | Hbp |
Name Aliases: | HSE1 homolog (S. cerevisiae) |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1929100 | Rat Genome Database ID: | RGD:1311497 |
HGNC ID: | HGNC:11358 | RefSeq IDs: | NM_005843 |
Entrez Gene ID: | 10254 | Ensembl Gene ID: | ENSG00000115145 |
VEGA IDs: | OTTHUMG00000131885 | UniProt ID: | O75886 |
UCSC ID: | uc002tyc.3 | OMIM ID: | 606244 |
Pubmed: | PMID10899310 PMID 10993906 | ||
CCDS IDs: | CCDSCCDS2196.1 |
Signal transducing adapter molecule 2 is a protein that in humans is encoded by the STAM2 gene. The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
Products for STAM2 gene
Catalog | Product Name | Application | Company |
GFS:E01248 | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2; ELISA kit | ELISA | n/a |
GFS:A01248 | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2; Anti | ANTIBODIES | n/a |
GFS:P01248 | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2; Protien | Protien | n/a |