Symbol: Name: ID: |
STAMBP STAM binding protein GFS:6040 |
Gene name: | STAMBP |
Chromosome: | 2p24.3-p24.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | AMSH |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1917777 | Rat Genome Database ID: | RGD:619963 |
HGNC ID: | HGNC:16950 | RefSeq IDs: | NM_006463 |
Entrez Gene ID: | 10617 | Ensembl Gene ID: | ENSG00000124356 |
VEGA IDs: | OTTHUMG00000129817 | UniProt ID: | O95630 |
UCSC ID: | uc002sjs.2 | OMIM ID: | 606247 |
Pubmed: | PMID10383417 | ||
CCDS IDs: | CCDSCCDS1929.1 |
STAM-binding protein is a protein that in humans is encoded by the STAMBP gene.
Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.
Products for STAMBP gene
Catalog | Product Name | Application | Company |
GFS:E06040 | STAM binding protein; ELISA kit | ELISA | n/a |
GFS:A06040 | STAM binding protein; Anti | ANTIBODIES | n/a |
GFS:P06040 | STAM binding protein; Protien | Protien | n/a |