Symbol: Name: ID: |
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 GFS:1247 |
Gene name: | STAM |
Chromosome: | 10p14-p13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | STAM1 |
Name Aliases: | HSE1 homolog (S. cerevisiae) |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1329014 | Rat Genome Database ID: | RGD:1564499 |
HGNC ID: | HGNC:11357 | RefSeq IDs: | NM_003473 |
Entrez Gene ID: | 8027 | Ensembl Gene ID: | ENSG00000136738 |
VEGA IDs: | OTTHUMG00000017749 | UniProt ID: | Q92783 |
UCSC ID: | uc001ipj.1 | OMIM ID: | 601899 |
Pubmed: | PMID8780729 | ||
CCDS IDs: | CCDSCCDS7122.1 |
Signal transducing adapter molecule 1 is a protein that in humans is encoded by the STAM gene. This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq].
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
Products for STAM gene
Catalog | Product Name | Application | Company |
GFS:E01247 | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; ELISA kit | ELISA | n/a |
GFS:A01247 | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; Anti | ANTIBODIES | n/a |
GFS:P01247 | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; Protien | Protien | n/a |