Symbol: Name: ID: |
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 GFS:5381 |
Gene name: | SPTLC3 |
Chromosome: | 20p12.1 |
Previous Symbols: | C20orf38, SPTLC2L |
Previous Names: | chromosome 20 open reading frame 38, "serine palmitoyltransferase, long chain base subunit 2-like (aminotransferase 2)" |
Aliases: | LCB2B, FLJ11112 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2444678 | Rat Genome Database ID: | RGD:1310030 |
HGNC ID: | HGNC:16253 | RefSeq IDs: | NM_018327 |
Entrez Gene ID: | 55304 | Ensembl Gene ID: | ENSG00000172296 |
VEGA IDs: | OTTHUMG00000031899 | UniProt ID: | Q9NUV7 |
UCSC ID: | uc002wod.1 | OMIM ID: | 611120 |
Pubmed: | PMID17023427 | ||
CCDS IDs: | CCDSCCDS13115.2 |
The SPTLC3 gene encodes an isoform of the third subunit of serine palmitoyltransferase (SPT; EC 2.3.1.50), which catalyzes the rate-limiting step of the de novo synthesis of sphingolipids (Hornemann et al., 2006 [PubMed 17023427]). SPT contains 2 main subunits: the common SPTLC1 subunit (MIM 605712) and either SPTLC2 (MIM 605713) or its isoform SPTLC2L (SPTLC3), depending on the tissue in which biosynthesis occurs (Hornemann et al., 2006 [PubMed 17023427]). There are also 2 highly related isoforms of a third subunit, SSSPTA (MIM 613540) and SSSPTB (MIM 610412), that confer acyl-CoA preference of the SPT enzyme and are essential for maximal enzyme activity (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SSSPTA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SSSPTB has the ability to use a broader range of acyl-CoAs without apparent preference.
Products for SPTLC3 gene
Catalog | Product Name | Application | Company |
GFS:E05381 | serine palmitoyltransferase, long chain base subunit 3; ELISA kit | ELISA | n/a |
GFS:A05381 | serine palmitoyltransferase, long chain base subunit 3; Anti | ANTIBODIES | n/a |
GFS:P05381 | serine palmitoyltransferase, long chain base subunit 3; Protien | Protien | n/a |