Symbol: Name: ID: |
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 GFS:1170 |
Gene name: | SPTLC1 |
Chromosome: | 9q22.31 |
Previous Symbols: | HSN1 |
Previous Names: | hereditary sensory neuropathy, type 1 |
Aliases: | LCB1, SPTI, HSAN1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1099431 | Rat Genome Database ID: | RGD:1307140 |
HGNC ID: | HGNC:11277 | RefSeq IDs: | NM_006415 |
Entrez Gene ID: | 10558 | Ensembl Gene ID: | ENSG00000090054 |
VEGA IDs: | OTTHUMG00000021047 | UniProt ID: | O15269 |
UCSC ID: | uc004arl.1 | OMIM ID: | 605712 |
Pubmed: | PMID9363775 | ||
CCDS IDs: | CCDSCCDS6692.1 CCDS CCDS6693.1 |
Serine palmitoyltransferase, long chain base subunit 1, also known as SPTLC1, is a protein which in humans is encoded by the SPTLC1 gene. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq].
Serine palmitoyltransferase (SPT). The heterodimer formed with LCB2 (SPTLC2 or SPTLC3) constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SSSPTA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SSSPTA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SSSPTB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SSSPTB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.
Products for SPTLC1 gene
Catalog | Product Name | Application | Company |
GFS:E01170 | serine palmitoyltransferase, long chain base subunit 1; ELISA kit | ELISA | n/a |
GFS:A01170 | serine palmitoyltransferase, long chain base subunit 1; Anti | ANTIBODIES | n/a |
GFS:P01170 | serine palmitoyltransferase, long chain base subunit 1; Protien | Protien | n/a |