Symbol: Name: ID: |
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 GFS:1171 |
Gene name: | SPTLC2 |
Chromosome: | 14q24.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0526, LCB2, LCB2A |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:108074 | Rat Genome Database ID: | RGD:1305447 |
HGNC ID: | HGNC:11278 | RefSeq IDs: | NM_004863 |
Entrez Gene ID: | 9517 | Ensembl Gene ID: | ENSG00000100596 |
VEGA IDs: | UniProt ID: | O15270 | |
UCSC ID: | uc001xub.2 | OMIM ID: | 605713 |
Pubmed: | PMID8921873 PMID 9363775 | ||
CCDS IDs: | CCDSCCDS9865.1 |
Serine palmitoyltransferase, long chain base subunit 2, also known as SPTLC2, is a protein which in humans is encoded by the SPTLC2 gene. This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SSSPTA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SSSPTB complex displays a preference for C18-CoA substrate.
Products for SPTLC2 gene
Catalog | Product Name | Application | Company |
GFS:E01171 | serine palmitoyltransferase, long chain base subunit 2; ELISA kit | ELISA | n/a |
GFS:A01171 | serine palmitoyltransferase, long chain base subunit 2; Anti | ANTIBODIES | n/a |
GFS:P01171 | serine palmitoyltransferase, long chain base subunit 2; Protien | Protien | n/a |