Symbol: Name: ID: |
SRSF10 serine/arginine-rich splicing factor 10 GFS:5810 |
Gene name: | SRSF10 |
Chromosome: | 1p36.11 |
Previous Symbols: | FUSIP2, FUSIP1, SFRS13A |
Previous Names: | FUS-interacting protein (serine-arginine rich) 2, "FUS interacting protein (serine/arginine-rich) 1", "splicing factor, arginine/serine-rich 13A", "neural-salient SR protein" |
Aliases: | TASR1, TASR2, SRp38, SRrp40, SFRS13, NSSR |
Name Aliases: | splicing factor, arginine/serine-rich 13, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1333805 | Rat Genome Database ID: | |
HGNC ID: | HGNC:16713 | RefSeq IDs: | NM_001191005 |
Entrez Gene ID: | 10772 | Ensembl Gene ID: | ENSG00000188529 |
VEGA IDs: | OTTHUMG00000013893 | UniProt ID: | O75494 |
UCSC ID: | uc010oee.1 | OMIM ID: | 605221 |
Pubmed: | PMID11891055 PMID 20516191 | ||
CCDS IDs: | CCDSCCDS30629.1 CCDS CCDS30630.1 |
FUS-interacting serine-arginine-rich protein 1 is a protein that in humans is encoded by the SFRS13A gene.
This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing. This gene has multiple pseudogenes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist.[provided by RefSeq, Jul 2010].
Function: Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.
Products for SRSF10 gene
Catalog | Product Name | Application | Company |
GFS:E05810 | serine/arginine-rich splicing factor 10; ELISA kit | ELISA | n/a |
GFS:A05810 | serine/arginine-rich splicing factor 10; Anti | ANTIBODIES | n/a |
GFS:P05810 | serine/arginine-rich splicing factor 10; Protien | Protien | n/a |