Symbol: Name: ID: |
POF1B premature ovarian failure, 1B GFS:3221 |
Gene name: | POF1B |
Chromosome: | Xq21.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | POF, FLJ22792 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1916943 | Rat Genome Database ID: | RGD:1560798 |
HGNC ID: | HGNC:13711 | RefSeq IDs: | NM_024921 |
Entrez Gene ID: | 79983 | Ensembl Gene ID: | ENSG00000124429 |
VEGA IDs: | OTTHUMG00000021934 | UniProt ID: | Q8WVV4 |
UCSC ID: | uc004eer.2 | OMIM ID: | 300603 |
Pubmed: | PMID11299520 | ||
CCDS IDs: | CCDSCCDS14452.1 |
Protein POF1B is a protein that in humans is encoded by the POF1B gene.
Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called 'POF1' and 'POF2' have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined. [provided by RefSeq, Jan 2010].
Function: May be involved in ovary development.
Products for POF1B gene
Catalog | Product Name | Application | Company |
GFS:E03221 | premature ovarian failure, 1B; ELISA kit | ELISA | n/a |
GFS:A03221 | premature ovarian failure, 1B; Anti | ANTIBODIES | n/a |
GFS:P03221 | premature ovarian failure, 1B; Protien | Protien | n/a |