Symbol: Name: ID: |
PIWIL4 piwi-like 4 (Drosophila) GFS:7294 |
Gene name: | PIWIL4 |
Chromosome: | 11q12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FLJ36156, HIWI2, Miwi2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:3041167 | Rat Genome Database ID: | RGD:1311015 |
HGNC ID: | HGNC:18444 | RefSeq IDs: | NM_152431 |
Entrez Gene ID: | 143689 | Ensembl Gene ID: | ENSG00000134627 |
VEGA IDs: | UniProt ID: | Q7Z3Z4 | |
UCSC ID: | uc001pfa.2 | OMIM ID: | 610315 |
Pubmed: | PMID12906857 | ||
CCDS IDs: | CCDSCCDS31656.1 |
PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008].
Function: Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association. The piRNA process acts upstream of known mediators of DNA methylation. Participates to a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). May be involved in the chromatin-modifying pathway by inducing 'Lys-9' methylation of histone H3 at some loci.
Products for PIWIL4 gene
Catalog | Product Name | Application | Company |
GFS:E07294 | piwi-like 4 (Drosophila); ELISA kit | ELISA | n/a |
GFS:A07294 | piwi-like 4 (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P07294 | piwi-like 4 (Drosophila); Protien | Protien | n/a |