Symbol: Name: ID: |
PIWIL2 piwi-like 2 (Drosophila) GFS:6600 |
Gene name: | PIWIL2 |
Chromosome: | 8p24 |
Previous Symbols: | |
Previous Names: | |
Aliases: | HILI, FLJ10351, Mili, CT80 |
Name Aliases: | Hiwi-like, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1930036 | Rat Genome Database ID: | RGD:1306964 |
HGNC ID: | HGNC:17644 | RefSeq IDs: | NM_001135721 |
Entrez Gene ID: | 55124 | Ensembl Gene ID: | ENSG00000197181 |
VEGA IDs: | OTTHUMG00000097767 | UniProt ID: | Q8TC59 |
UCSC ID: | uc003xbn.2 | OMIM ID: | 610312 |
Pubmed: | PMID11279525 PMID 12906857 | ||
CCDS IDs: | CCDSCCDS6029.1 |
PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008].
Function: Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate to similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with primary piRNAs in the cytoplasm and is required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense. The piRNA process acts upstream of known mediators of DNA methylation. Participates to a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Indirectly modulate expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (By similarity).
Products for PIWIL2 gene
Catalog | Product Name | Application | Company |
GFS:E06600 | piwi-like 2 (Drosophila); ELISA kit | ELISA | n/a |
GFS:A06600 | piwi-like 2 (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P06600 | piwi-like 2 (Drosophila); Protien | Protien | n/a |