Symbol: Name: ID: |
PIWIL3 piwi-like 3 (Drosophila) GFS:7293 |
Gene name: | PIWIL3 |
Chromosome: | 22q11.23 |
Previous Symbols: | |
Previous Names: | |
Aliases: | HIWI3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:18443 | RefSeq IDs: | NM_001008496 |
Entrez Gene ID: | 440822 | Ensembl Gene ID: | ENSG00000184571 |
VEGA IDs: | OTTHUMG00000150788 | UniProt ID: | Q7Z3Z3 |
UCSC ID: | uc003abd.1 | OMIM ID: | 610314 |
Pubmed: | PMID12906857 | ||
CCDS IDs: | CCDSCCDS33623.1 |
PIWIL3 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008].
Function: May play a role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).
Products for PIWIL3 gene
Catalog | Product Name | Application | Company |
GFS:E07293 | piwi-like 3 (Drosophila); ELISA kit | ELISA | n/a |
GFS:A07293 | piwi-like 3 (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P07293 | piwi-like 3 (Drosophila); Protien | Protien | n/a |