Symbol: Name: ID: |
PLA1A phospholipase A1 member A GFS:6610 |
Gene name: | PLA1A |
Chromosome: | 3q13.13-q13.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ps-PLA1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1934677 | Rat Genome Database ID: | RGD:621261 |
HGNC ID: | HGNC:17661 | RefSeq IDs: | NM_015900 |
Entrez Gene ID: | 51365 | Ensembl Gene ID: | ENSG00000144837 |
VEGA IDs: | OTTHUMG00000159425 | UniProt ID: | Q53H76 |
UCSC ID: | uc003ecu.2 | OMIM ID: | 607460 |
Pubmed: | PMID10196188 | ||
CCDS IDs: | CCDSCCDS2991.1 |
The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011].
Function: Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.
Products for PLA1A gene
Catalog | Product Name | Application | Company |
GFS:E06610 | phospholipase A1 member A; ELISA kit | ELISA | n/a |
GFS:A06610 | phospholipase A1 member A; Anti | ANTIBODIES | n/a |
GFS:P06610 | phospholipase A1 member A; Protien | Protien | n/a |