Symbol: Name: ID: |
PRX periaxin GFS:3278 |
Gene name: | PRX |
Chromosome: | 19q13.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA1620 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:108176 | Rat Genome Database ID: | RGD:619960 |
HGNC ID: | HGNC:13797 | RefSeq IDs: | NM_020956 |
Entrez Gene ID: | 57716 | Ensembl Gene ID: | ENSG00000105227 |
VEGA IDs: | UniProt ID: | Q9BXM0 | |
UCSC ID: | uc002onr.2 | OMIM ID: | 605725 |
Pubmed: | PMID10839370 PMID 9143514 | ||
CCDS IDs: | CCDSCCDS12556.1 CCDS CCDS33028.1 |
Periaxin is a protein that in humans is encoded by the PRX gene.
This gene encodes a protein involved in peripheral nerve myelin upkeep. The encoded protein contains 2 PDZ domains which were named after PSD95 (post synaptic density protein), DlgA (Drosophila disc large tumor suppressor), and ZO1 (a mammalian tight junction protein). Two alternatively spliced transcript variants have been described for this gene which encode different protein isoforms and which are targeted differently in the Schwann cell. Mutations in this gene cause Charcot-Marie-Tooth neuoropathy, type 4F and Dejerine-Sottas neuropathy. [provided by RefSeq, Jul 2008].
Function: Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition.
Products for PRX gene
Catalog | Product Name | Application | Company |
GFS:E03278 | periaxin; ELISA kit | ELISA | n/a |
GFS:A03278 | periaxin; Anti | ANTIBODIES | n/a |
GFS:P03278 | periaxin; Protien | Protien | n/a |