Symbol: Name: ID: |
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 GFS:5184 |
Gene name: | PAK4 |
Chromosome: | 19p11-q11 |
Previous Symbols: | |
Previous Names: | p21(CDKN1A)-activated kinase 4 |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1917834 | Rat Genome Database ID: | RGD:1307705 |
HGNC ID: | HGNC:16059 | RefSeq IDs: | NM_001014831 |
Entrez Gene ID: | 10298 | Ensembl Gene ID: | ENSG00000130669 |
VEGA IDs: | UniProt ID: | O96013 | |
UCSC ID: | uc002okn.1 | OMIM ID: | 605451 |
Pubmed: | PMID9822598 PMID 10461188 | ||
CCDS IDs: | CCDSCCDS12528.1 CCDS CCDS33019.1 |
Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene.
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2.
Products for PAK4 gene
Catalog | Product Name | Application | Company |
GFS:E05184 | p21 protein (Cdc42/Rac)-activated kinase 4; ELISA kit | ELISA | n/a |
GFS:A05184 | p21 protein (Cdc42/Rac)-activated kinase 4; Anti | ANTIBODIES | n/a |
GFS:P05184 | p21 protein (Cdc42/Rac)-activated kinase 4; Protien | Protien | n/a |