Symbol: Name: ID: |
ORC6 origin recognition complex, subunit 6 GFS:6239 |
Gene name: | ORC6 |
Chromosome: | 16q12 |
Previous Symbols: | ORC6L |
Previous Names: | origin recognition complex, subunit 6 homolog-like (yeast), "origin recognition complex, subunit 6 like (yeast)" |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1929285 | Rat Genome Database ID: | RGD:1311437 |
HGNC ID: | HGNC:17151 | RefSeq IDs: | NM_014321 |
Entrez Gene ID: | 23594 | Ensembl Gene ID: | ENSG00000091651 |
VEGA IDs: | OTTHUMG00000132539 | UniProt ID: | Q9Y5N6 |
UCSC ID: | uc002eeh.2 | OMIM ID: | 607213 |
Pubmed: | PMID10945994 | ||
CCDS IDs: | CCDSCCDS10722.1 |
Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6L gene.
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010].
Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Products for ORC6 gene
Catalog | Product Name | Application | Company |
GFS:E06239 | origin recognition complex, subunit 6; ELISA kit | ELISA | n/a |
GFS:A06239 | origin recognition complex, subunit 6; Anti | ANTIBODIES | n/a |
GFS:P06239 | origin recognition complex, subunit 6; Protien | Protien | n/a |