Symbol: Name: ID: |
MLL3 myeloid/lymphoid or mixed-lineage leukemia 3 GFS:3232 |
Gene name: | MLL3 |
Chromosome: | 7q36 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA1506, HALR, KMT2C |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2444959 | Rat Genome Database ID: | |
HGNC ID: | HGNC:13726 | RefSeq IDs: | NM_170606 |
Entrez Gene ID: | 58508 | Ensembl Gene ID: | ENSG00000055609 |
VEGA IDs: | OTTHUMG00000150553 | UniProt ID: | Q8NEZ4 |
UCSC ID: | uc003wla.2 | OMIM ID: | 606833 |
Pubmed: | PMID10819331 | ||
CCDS IDs: | CCDSCCDS5931.1 |
Histone-lysine N-methyltransferase MLL3 is an enzyme that in humans is encoded by the MLL3 gene.
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/MLL3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.
Products for MLL3 gene
Catalog | Product Name | Application | Company |
GFS:E03232 | myeloid/lymphoid or mixed-lineage leukemia 3; ELISA kit | ELISA | n/a |
GFS:A03232 | myeloid/lymphoid or mixed-lineage leukemia 3; Anti | ANTIBODIES | n/a |
GFS:P03232 | myeloid/lymphoid or mixed-lineage leukemia 3; Protien | Protien | n/a |