Symbol: Name: ID: |
MED4 mediator complex subunit 4 GFS:6803 |
Gene name: | MED4 |
Chromosome: | 13q14.12 |
Previous Symbols: | VDRIP |
Previous Names: | vitamin D receptor interacting protein, "mediator of RNA polymerase II transcription, subunit 4 homolog (S. cerevisiae)" |
Aliases: | HSPC126, DRIP36, TRAP36 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914631 | Rat Genome Database ID: | RGD:1306671 |
HGNC ID: | HGNC:17903 | RefSeq IDs: | NM_014166 |
Entrez Gene ID: | 29079 | Ensembl Gene ID: | ENSG00000136146 |
VEGA IDs: | OTTHUMG00000016891 | UniProt ID: | Q9NPJ6 |
UCSC ID: | uc001vby.1 | OMIM ID: | 605718 |
Pubmed: | PMID10235266 PMID 11042152 | ||
CCDS IDs: | CCDSCCDS9408.1 |
Mediator of RNA polymerase II transcription subunit 4 also known as mediator complex subunit 4 (MED4) or vitamin D3 receptor-interacting protein complex 36 kDa component (DRIP36) is a protein that in humans is encoded by the MED4 gene.
The Mediator is a multiprotein coactivator that is required by DNA-binding transcription factors for activation of polymerase II (see MIM 180660)-transcribed genes. MED4 appears to be a core Mediator subunit and is found in nearly all Mediator preparations (summary by Sato et al., 2004 [PubMed 15175163]).[supplied by OMIM, Nov 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Products for MED4 gene
Catalog | Product Name | Application | Company |
GFS:E06803 | mediator complex subunit 4; ELISA kit | ELISA | n/a |
GFS:A06803 | mediator complex subunit 4; Anti | ANTIBODIES | n/a |
GFS:P06803 | mediator complex subunit 4; Protien | Protien | n/a |