Symbol: Name: ID: |
L3MBTL1 l(3)mbt-like 1 (Drosophila) GFS:5039 |
Gene name: | L3MBTL1 |
Chromosome: | 20q13.12 |
Previous Symbols: | L3MBTL |
Previous Names: | l(3)mbt (Drosophila)-like, "l(3)mbt-like (Drosophila)" |
Aliases: | dJ138B7.3, DKFZp586P1522, KIAA0681 |
Name Aliases: | lethal (3) malignant brain tumor l(3) |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2676663 | Rat Genome Database ID: | RGD:1307316 |
HGNC ID: | HGNC:15905 | RefSeq IDs: | NM_015478 |
Entrez Gene ID: | 26013 | Ensembl Gene ID: | ENSG00000185513 |
VEGA IDs: | OTTHUMG00000032503 | UniProt ID: | Q9Y468 |
UCSC ID: | uc002xkl.2 | OMIM ID: | 608802 |
Pubmed: | PMID10445843 PMID 17540172 | ||
CCDS IDs: | CCDSCCDS13319.1 CCDS CCDS46602.1 |
Lethal(3)malignant brain tumor-like protein is a protein that in humans is encoded by the L3MBTL gene.
This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010].
Function: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
Products for L3MBTL1 gene
Catalog | Product Name | Application | Company |
GFS:E05039 | l(3)mbt-like 1 (Drosophila); ELISA kit | ELISA | n/a |
GFS:A05039 | l(3)mbt-like 1 (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P05039 | l(3)mbt-like 1 (Drosophila); Protien | Protien | n/a |