Symbol: Name: ID: |
IPO13 importin 13 GFS:5940 |
Gene name: | IPO13 |
Chromosome: | 1p34.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | IMP13, KIAA0724, RANBP13 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2385205 | Rat Genome Database ID: | RGD:620071 |
HGNC ID: | HGNC:16853 | RefSeq IDs: | NM_014652 |
Entrez Gene ID: | 9670 | Ensembl Gene ID: | ENSG00000117408 |
VEGA IDs: | OTTHUMG00000008297 | UniProt ID: | O94829 |
UCSC ID: | uc001ckx.2 | OMIM ID: | 610411 |
Pubmed: | PMID9872452 PMID 11447110 | ||
CCDS IDs: | CCDSCCDS503.1 |
Importin-13 is a protein that in humans is encoded by the IPO13 gene.
This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.
Products for IPO13 gene
Catalog | Product Name | Application | Company |
GFS:E05940 | importin 13; ELISA kit | ELISA | n/a |
GFS:A05940 | importin 13; Anti | ANTIBODIES | n/a |
GFS:P05940 | importin 13; Protien | Protien | n/a |