Symbol: Name: ID: |
ADIPOQ adiponectin, C1Q and collagen domain containing GFS:3173 |
Gene name: | ADIPOQ |
Chromosome: | 3q27 |
Previous Symbols: | ACDC |
Previous Names: | adipocyte, C1Q and collagen domain containing |
Aliases: | ACRP30, AdipoQ, apM1, GBP28, adiponectin |
Name Aliases: | adipose most abundant gene transcript 1 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:106675 | Rat Genome Database ID: | RGD:628748 |
HGNC ID: | HGNC:13633 | RefSeq IDs: | NM_001177800 |
Entrez Gene ID: | 9370 | Ensembl Gene ID: | ENSG00000181092 |
VEGA IDs: | OTTHUMG00000156521 | UniProt ID: | Q15848 |
UCSC ID: | uc003fra.2 | OMIM ID: | 605441 |
Pubmed: | PMID7592907 PMID 8631877 | ||
CCDS IDs: | CCDSCCDS3284.1 |
Adiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is a protein which in humans is encoded by the ADIPOQ gene.
This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010].
Function: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Products for ADIPOQ gene
Catalog | Product Name | Application | Company |
GFS:E03173 | adiponectin, C1Q and collagen domain containing; ELISA kit | ELISA | n/a |
GFS:A03173 | adiponectin, C1Q and collagen domain containing; Anti | ANTIBODIES | n/a |
GFS:P03173 | adiponectin, C1Q and collagen domain containing; Protien | Protien | n/a |