Symbol: Name: ID: |
HOMER3 homer homolog 3 (Drosophila) GFS:6533 |
Gene name: | HOMER3 |
Chromosome: | 19p13.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | HOMER-3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1347359 | Rat Genome Database ID: | RGD:620706 |
HGNC ID: | HGNC:17514 | RefSeq IDs: | NM_001145721 |
Entrez Gene ID: | 9454 | Ensembl Gene ID: | ENSG00000051128 |
VEGA IDs: | UniProt ID: | Q9NSC5 | |
UCSC ID: | uc002nkv.2 | OMIM ID: | 604800 |
Pubmed: | PMID10653696 PMID 9808459 | ||
CCDS IDs: | CCDSCCDS12391.1 CCDS CCDS46022.1 CCDS CCDS46023.1 |
Homer protein homolog 3 is a protein that in humans is encoded by the HOMER3 gene.
This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009].
Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
Products for HOMER3 gene
Catalog | Product Name | Application | Company |
GFS:E06533 | homer homolog 3 (Drosophila); ELISA kit | ELISA | n/a |
GFS:A06533 | homer homolog 3 (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P06533 | homer homolog 3 (Drosophila); Protien | Protien | n/a |