Symbol: Name: ID: |
HOMER1 homer homolog 1 (Drosophila) GFS:6531 |
Gene name: | HOMER1 |
Chromosome: | 5q14.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | Ves-1, SYN47, HOMER-1B |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1347345 | Rat Genome Database ID: | RGD:628725 |
HGNC ID: | HGNC:17512 | RefSeq IDs: | NM_004272 |
Entrez Gene ID: | 9456 | Ensembl Gene ID: | ENSG00000152413 |
VEGA IDs: | OTTHUMG00000134278 | UniProt ID: | Q86YM7 |
UCSC ID: | uc003kfy.2 | OMIM ID: | 604798 |
Pubmed: | PMID9808459 PMID 9808458 | ||
CCDS IDs: | CCDSCCDS43335.1 |
Homer protein homolog 1 or Homer1 is a neuronal protein that in humans is encoded by the HOMER1 gene.
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
Products for HOMER1 gene
Catalog | Product Name | Application | Company |
GFS:E06531 | homer homolog 1 (Drosophila); ELISA kit | ELISA | n/a |
GFS:A06531 | homer homolog 1 (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P06531 | homer homolog 1 (Drosophila); Protien | Protien | n/a |