Symbol: Name: ID: |
HOMER2 homer homolog 2 (Drosophila) GFS:6532 |
Gene name: | HOMER2 |
Chromosome: | 15q24.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CPD, Cupidin, Vesl-2, HOMER-2B, HOMER-2, HOMER-2A |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1347354 | Rat Genome Database ID: | RGD:620705 |
HGNC ID: | HGNC:17513 | RefSeq IDs: | NM_004839 |
Entrez Gene ID: | 9455 | Ensembl Gene ID: | ENSG00000103942 |
VEGA IDs: | UniProt ID: | Q9NSB8 | |
UCSC ID: | uc002bjg.2 | OMIM ID: | 604799 |
Pubmed: | PMID9808459 PMID 9808458 | ||
CCDS IDs: | CCDSCCDS45334.1 CCDS CCDS45335.1 CCDS CCDS45336.1 CCDS CCDS45337.1 |
Homer protein homolog 2 is a protein that in humans is encoded by the HOMER2 gene.
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011].
Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
Products for HOMER2 gene
Catalog | Product Name | Application | Company |
GFS:E06532 | homer homolog 2 (Drosophila); ELISA kit | ELISA | n/a |
GFS:A06532 | homer homolog 2 (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P06532 | homer homolog 2 (Drosophila); Protien | Protien | n/a |