Symbol: Name: ID: |
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 GFS:6172 |
Gene name: | GGA3 |
Chromosome: | 17q25 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0154 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2384159 | Rat Genome Database ID: | RGD:1309553 |
HGNC ID: | HGNC:17079 | RefSeq IDs: | NM_001172703 |
Entrez Gene ID: | 23163 | Ensembl Gene ID: | ENSG00000125447 |
VEGA IDs: | UniProt ID: | Q9NZ52 | |
UCSC ID: | uc002jni.1 | OMIM ID: | 606006 |
Pubmed: | PMID10747089 PMID 10749927 | ||
CCDS IDs: | CCDSCCDS11716.1 CCDS CCDS11717.1 |
ADP-ribosylation factor-binding protein GGA3 is a protein that in humans is encoded by the GGA3 gene.
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010].
Function: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.
Products for GGA3 gene
Catalog | Product Name | Application | Company |
GFS:E06172 | golgi-associated, gamma adaptin ear containing, ARF binding protein 3; ELISA kit | ELISA | n/a |
GFS:A06172 | golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Anti | ANTIBODIES | n/a |
GFS:P06172 | golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Protien | Protien | n/a |