Symbol: Name: ID: |
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 GFS:6743 |
Gene name: | GGA1 |
Chromosome: | 22q13.31 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2146207 | Rat Genome Database ID: | RGD:1307770 |
HGNC ID: | HGNC:17842 | RefSeq IDs: | NM_001001560 |
Entrez Gene ID: | 26088 | Ensembl Gene ID: | ENSG00000100083 |
VEGA IDs: | OTTHUMG00000030985 | UniProt ID: | Q9UJY5 |
UCSC ID: | uc003atc.2 | OMIM ID: | 606004 |
Pubmed: | PMID10747088 PMID 10747089 PMID 16407204 | ||
CCDS IDs: | CCDSCCDS13951.1 CCDS CCDS33643.1 CCDS CCDS46704.1 |
ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene.
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.
Products for GGA1 gene
Catalog | Product Name | Application | Company |
GFS:E06743 | golgi-associated, gamma adaptin ear containing, ARF binding protein 1; ELISA kit | ELISA | n/a |
GFS:A06743 | golgi-associated, gamma adaptin ear containing, ARF binding protein 1; Anti | ANTIBODIES | n/a |
GFS:P06743 | golgi-associated, gamma adaptin ear containing, ARF binding protein 1; Protien | Protien | n/a |