Symbol: Name: ID: |
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 GFS:5190 |
Gene name: | GGA2 |
Chromosome: | 16p12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | VEAR, KIAA1080 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1921355 | Rat Genome Database ID: | RGD:1304800 |
HGNC ID: | HGNC:16064 | RefSeq IDs: | NM_015044 |
Entrez Gene ID: | 23062 | Ensembl Gene ID: | ENSG00000103365 |
VEGA IDs: | OTTHUMG00000096957 | UniProt ID: | Q9UJY4 |
UCSC ID: | uc002dlq.2 | OMIM ID: | 606005 |
Pubmed: | PMID10747088 PMID 10749927 | ||
CCDS IDs: | CCDSCCDS10611.1 |
ADP-ribosylation factor-binding protein GGA2 is a protein that in humans is encoded by the GGA2 gene.
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.
Products for GGA2 gene
Catalog | Product Name | Application | Company |
GFS:E05190 | golgi-associated, gamma adaptin ear containing, ARF binding protein 2; ELISA kit | ELISA | n/a |
GFS:A05190 | golgi-associated, gamma adaptin ear containing, ARF binding protein 2; Anti | ANTIBODIES | n/a |
GFS:P05190 | golgi-associated, gamma adaptin ear containing, ARF binding protein 2; Protien | Protien | n/a |