Symbol: Name: ID: |
EIF2C3 eukaryotic translation initiation factor 2C, 3 GFS:7279 |
Gene name: | EIF2C3 |
Chromosome: | 1p34 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FLJ12765, AGO3 |
Name Aliases: | argonaute 3 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2446634 | Rat Genome Database ID: | RGD:1309163 |
HGNC ID: | HGNC:18421 | RefSeq IDs: | NM_024852 |
Entrez Gene ID: | 192669 | Ensembl Gene ID: | ENSG00000126070 |
VEGA IDs: | OTTHUMG00000007533 | UniProt ID: | Q9H9G7 |
UCSC ID: | uc001bzp.2 | OMIM ID: | 607355 |
Pubmed: | PMID12906857 | ||
CCDS IDs: | CCDSCCDS399.1 CCDS CCDS400.1 |
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.
Products for EIF2C3 gene
Catalog | Product Name | Application | Company |
GFS:E07279 | eukaryotic translation initiation factor 2C, 3; ELISA kit | ELISA | n/a |
GFS:A07279 | eukaryotic translation initiation factor 2C, 3; Anti | ANTIBODIES | n/a |
GFS:P07279 | eukaryotic translation initiation factor 2C, 3; Protien | Protien | n/a |