Symbol: Name: ID: |
ELMO1 engulfment and cell motility 1 GFS:5412 |
Gene name: | ELMO1 |
Chromosome: | 7p14.1 |
Previous Symbols: | |
Previous Names: | engulfment and cell motility 1 (ced-12 homolog, C. elegans) |
Aliases: | KIAA0281, CED12, ELMO-1, CED-12 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2153044 | Rat Genome Database ID: | RGD:1308182 |
HGNC ID: | HGNC:16286 | RefSeq IDs: | NM_001039459 |
Entrez Gene ID: | 9844 | Ensembl Gene ID: | ENSG00000155849 |
VEGA IDs: | OTTHUMG00000023701 | UniProt ID: | Q92556 |
UCSC ID: | uc003tfk.1 | OMIM ID: | 606420 |
Pubmed: | PMID11595183 | ||
CCDS IDs: | CCDSCCDS5449.1 CCDS CCDS5450.1 |
Engulfment and cell motility protein 1 is a protein that in humans is encoded by the ELMO1 gene. ELMO1 is located on chromosome number seven in humans and is located on chromosome number thirteen in mice.
This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011].
Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
Products for ELMO1 gene
Catalog | Product Name | Application | Company |
GFS:E05412 | engulfment and cell motility 1; ELISA kit | ELISA | n/a |
GFS:A05412 | engulfment and cell motility 1; Anti | ANTIBODIES | n/a |
GFS:P05412 | engulfment and cell motility 1; Protien | Protien | n/a |