Symbol: Name: ID: |
DUSP18 dual specificity phosphatase 18 GFS:7330 |
Gene name: | DUSP18 |
Chromosome: | 22q12.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | DUSP20 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1922469 | Rat Genome Database ID: | RGD:1306929 |
HGNC ID: | HGNC:18484 | RefSeq IDs: | NM_152511 |
Entrez Gene ID: | 150290 | Ensembl Gene ID: | ENSG00000167065 |
VEGA IDs: | UniProt ID: | Q8NEJ0 | |
UCSC ID: | uc003aiw.1 | OMIM ID: | 611446 |
Pubmed: | PMID12408986 | ||
CCDS IDs: | CCDSCCDS13883.1 |
Dual specificity protein phosphatase 18 is an enzyme that in humans is encoded by the DUSP18 gene.
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009].
Function: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).
Products for DUSP18 gene
Catalog | Product Name | Application | Company |
GFS:E07330 | dual specificity phosphatase 18; ELISA kit | ELISA | n/a |
GFS:A07330 | dual specificity phosphatase 18; Anti | ANTIBODIES | n/a |
GFS:P07330 | dual specificity phosphatase 18; Protien | Protien | n/a |