Symbol: Name: ID: |
CST9 cystatin 9 (testatin) GFS:2908 |
Gene name: | CST9 |
Chromosome: | 20p11.21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CLM |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:13261 | RefSeq IDs: | NM_001008693 |
Entrez Gene ID: | 128822 | Ensembl Gene ID: | ENSG00000173335 |
VEGA IDs: | OTTHUMG00000032076 | UniProt ID: | Q5W186 |
UCSC ID: | uc002wtl.2 | OMIM ID: | |
Pubmed: | |||
CCDS IDs: | CCDSCCDS33450.1 |
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted protein that may play a role in hematopoietic differentiation or inflammation. [provided by RefSeq]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
Function: Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.
Products for CST9 gene
Catalog | Product Name | Application | Company |
GFS:E02908 | cystatin 9 (testatin); ELISA kit | ELISA | n/a |
GFS:A02908 | cystatin 9 (testatin); Anti | ANTIBODIES | n/a |
GFS:P02908 | cystatin 9 (testatin); Protien | Protien | n/a |