Symbol: Name: ID: |
NCSTN nicastrin GFS:6186 |
Gene name: | NCSTN |
Chromosome: | 1q22-q23 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0253, APH2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1891700 | Rat Genome Database ID: | RGD:631418 |
HGNC ID: | HGNC:17091 | RefSeq IDs: | NM_015331 |
Entrez Gene ID: | 23385 | Ensembl Gene ID: | ENSG00000162736 |
VEGA IDs: | OTTHUMG00000033110 | UniProt ID: | Q92542 |
UCSC ID: | uc001fvx.2 | OMIM ID: | 605254 |
Pubmed: | PMID9039502 PMID 10993067 | ||
CCDS IDs: | CCDSCCDS1203.1 |
Nicastrin, also known as NCSTN, is a protein which in humans is encoded by the NCSTN gene.
This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Products for NCSTN gene
Catalog | Product Name | Application | Company |
GFS:E06186 | nicastrin; ELISA kit | ELISA | n/a |
GFS:A06186 | nicastrin; Anti | ANTIBODIES | n/a |
GFS:P06186 | nicastrin; Protien | Protien | n/a |