Symbol: Name: ID: |
C8G complement component 8, gamma polypeptide GFS:3093 |
Gene name: | C8G |
Chromosome: | 9q |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88237 | Rat Genome Database ID: | RGD:1309074 |
HGNC ID: | HGNC:1354 | RefSeq IDs: | NM_000606 |
Entrez Gene ID: | 733 | Ensembl Gene ID: | ENSG00000176919 |
VEGA IDs: | OTTHUMG00000020955 | UniProt ID: | P07360 |
UCSC ID: | uc004cka.2 | OMIM ID: | 120930 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS7017.1 |
The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.
Products for C8G gene
Catalog | Product Name | Application | Company |
GFS:E03093 | complement component 8, gamma polypeptide; ELISA kit | ELISA | n/a |
GFS:A03093 | complement component 8, gamma polypeptide; Anti | ANTIBODIES | n/a |
GFS:P03093 | complement component 8, gamma polypeptide; Protien | Protien | n/a |