Symbol: Name: ID: |
BCR breakpoint cluster region GFS:116 |
Gene name: | BCR |
Chromosome: | 22q11 |
Previous Symbols: | D22S11, BCR1 |
Previous Names: | |
Aliases: | D22S662, CML, PHL, ALL |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88141 | Rat Genome Database ID: | RGD:1307993 |
HGNC ID: | HGNC:1014 | RefSeq IDs: | NM_004327 |
Entrez Gene ID: | 613 | Ensembl Gene ID: | ENSG00000186716 |
VEGA IDs: | OTTHUMG00000150655 | UniProt ID: | P11274 |
UCSC ID: | uc002zuo.1 | OMIM ID: | 151410 |
Pubmed: | PMID1657398 PMID 18070886 | ||
CCDS IDs: | CCDSCCDS13806.1 CCDS CCDS13807.1 |
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. (provided byRefSeq)
Products for BCR gene
Catalog | Product Name | Application | Company |
GFS:E00116 | breakpoint cluster region; ELISA kit | ELISA | n/a |
GFS:A00116 | breakpoint cluster region; Anti | ANTIBODIES | n/a |
GFS:P00116 | breakpoint cluster region; Protien | Protien | n/a |