Symbol: Name: ID: |
C8A complement component 8, alpha polypeptide GFS:3074 |
Gene name: | C8A |
Chromosome: | 1p32.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2668347 | Rat Genome Database ID: | RGD:1308355 |
HGNC ID: | HGNC:1352 | RefSeq IDs: | NM_000562 |
Entrez Gene ID: | 731 | Ensembl Gene ID: | ENSG00000157131 |
VEGA IDs: | OTTHUMG00000008306 | UniProt ID: | P07357 |
UCSC ID: | uc001cyo.2 | OMIM ID: | 120950 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS606.1 |
C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.
Products for C8A gene
Catalog | Product Name | Application | Company |
GFS:E03074 | complement component 8, alpha polypeptide; ELISA kit | ELISA | n/a |
GFS:A03074 | complement component 8, alpha polypeptide; Anti | ANTIBODIES | n/a |
GFS:P03074 | complement component 8, alpha polypeptide; Protien | Protien | n/a |