Symbol: Name: ID: |
C5 complement component 5 GFS:2937 |
Gene name: | C5 |
Chromosome: | 9q33-q34 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CPAMD4 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:96031 | Rat Genome Database ID: | RGD:2237 |
HGNC ID: | HGNC:1331 | RefSeq IDs: | NM_001735 |
Entrez Gene ID: | 727 | Ensembl Gene ID: | |
VEGA IDs: | OTTHUMG00000020579 | UniProt ID: | P01031 |
UCSC ID: | uc004bkv.2 | OMIM ID: | 120900 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS6826.1 |
Complement component 5 is a protein that in humans is encoded by the C5 gene.
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for C5 gene
Catalog | Product Name | Application | Company |
GFS:E02937 | complement component 5; ELISA kit | ELISA | n/a |
GFS:A02937 | complement component 5; Anti | ANTIBODIES | n/a |
GFS:P02937 | complement component 5; Protien | Protien | n/a |