Symbol: Name: ID: |
C4A complement component 4A (Rodgers blood group) GFS:2882 |
Gene name: | C4A |
Chromosome: | 6p21.3 |
Previous Symbols: | |
Previous Names: | complement component 4A |
Aliases: | CPAMD2, C4S, CO4, C4, C4A3, C4A2, C4A4, C4A6, C4B, RG |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98320 | Rat Genome Database ID: | |
HGNC ID: | HGNC:1323 | RefSeq IDs: | NM_007293 |
Entrez Gene ID: | 720 | Ensembl Gene ID: | |
VEGA IDs: | OTTHUMG00000031186 | UniProt ID: | P0C0L4 |
UCSC ID: | uc011doy.1 | OMIM ID: | 120810 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS47404.1 |
Complement C4-A is a protein that in humans is encoded by the C4A gene.
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. [provided by RefSeq]. Sequence Note: This RefSeq record represents the C4A*001.1.1 allele. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for C4A gene
Catalog | Product Name | Application | Company |
GFS:E02882 | complement component 4A (Rodgers blood group); ELISA kit | ELISA | n/a |
GFS:A02882 | complement component 4A (Rodgers blood group); Anti | ANTIBODIES | n/a |
GFS:P02882 | complement component 4A (Rodgers blood group); Protien | Protien | n/a |