Symbol: Name: ID: |
C4BPB complement component 4 binding protein, beta GFS:2920 |
Gene name: | C4BPB |
Chromosome: | 1q32 |
Previous Symbols: | C4BP |
Previous Names: | complement component 4-binding protein, beta |
Aliases: | |
Name Aliases: | complement component 4 binding protein, beta chain, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:99594 | Rat Genome Database ID: | RGD:2236 |
HGNC ID: | HGNC:1328 | RefSeq IDs: | NM_000716 |
Entrez Gene ID: | 725 | Ensembl Gene ID: | ENSG00000123843 |
VEGA IDs: | OTTHUMG00000036035 | UniProt ID: | P20851 |
UCSC ID: | uc001hfj.2 | OMIM ID: | 120831 |
Pubmed: | PMID2300577 PMID 8325877 | ||
CCDS IDs: | CCDSCCDS1476.1 CCDS CCDS31005.1 |
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq].
Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.
Products for C4BPB gene
Catalog | Product Name | Application | Company |
GFS:E02920 | complement component 4 binding protein, beta; ELISA kit | ELISA | n/a |
GFS:A02920 | complement component 4 binding protein, beta; Anti | ANTIBODIES | n/a |
GFS:P02920 | complement component 4 binding protein, beta; Protien | Protien | n/a |