Symbol: Name: ID: |
C4BPA complement component 4 binding protein, alpha GFS:2901 |
Gene name: | C4BPA |
Chromosome: | 1q32 |
Previous Symbols: | C4BP |
Previous Names: | complement component 4-binding protein, alpha |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88229 | Rat Genome Database ID: | RGD:2235 |
HGNC ID: | HGNC:1325 | RefSeq IDs: | NM_000715 |
Entrez Gene ID: | 722 | Ensembl Gene ID: | ENSG00000123838 |
VEGA IDs: | OTTHUMG00000036173 | UniProt ID: | P04003 |
UCSC ID: | uc001hfo.2 | OMIM ID: | 120830 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS1477.1 |
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
Products for C4BPA gene
Catalog | Product Name | Application | Company |
GFS:E02901 | complement component 4 binding protein, alpha; ELISA kit | ELISA | n/a |
GFS:A02901 | complement component 4 binding protein, alpha; Anti | ANTIBODIES | n/a |
GFS:P02901 | complement component 4 binding protein, alpha; Protien | Protien | n/a |