Symbol: Name: ID: |
C1QC complement component 1, q subcomponent, C chain GFS:2243 |
Gene name: | C1QC |
Chromosome: | 1p36.11 |
Previous Symbols: | C1QG |
Previous Names: | complement component 1, q subcomponent, gamma polypeptide |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88225 | Rat Genome Database ID: | RGD:1306828 |
HGNC ID: | HGNC:1245 | RefSeq IDs: | NM_001114101 |
Entrez Gene ID: | 714 | Ensembl Gene ID: | |
VEGA IDs: | OTTHUMG00000002891 | UniProt ID: | P02747 |
UCSC ID: | uc001bga.3 | OMIM ID: | 120575 |
Pubmed: | PMID1706597 | ||
CCDS IDs: | CCDSCCDS227.1 |
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq].
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Products for C1QC gene
Catalog | Product Name | Application | Company |
GFS:E02243 | complement component 1, q subcomponent, C chain; ELISA kit | ELISA | n/a |
GFS:A02243 | complement component 1, q subcomponent, C chain; Anti | ANTIBODIES | n/a |
GFS:P02243 | complement component 1, q subcomponent, C chain; Protien | Protien | n/a |